6atb: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6atb is ~~ON HOLD until Paper Publication~~

==Crystal Structure of human NAMPT in complex with NVP-LOD812==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6atb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATB OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATB FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=BWA:N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N-[(pyridin-3-yl)methyl]urea'>BWA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atb OCA], [http://pdbe.org/6atb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atb RCSB], [http://www.ebi.ac.uk/pdbsum/6atb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atb ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

__TOC__

</StructureSection>

[[Category: Nicotinamide phosphoribosyltransferase]]

[[Category: Thigale, S]]

[[Category: Weihofen, W A]]

[[Category: Complex]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6atb is ON HOLD  until Paper Publication
+==Crystal Structure of human NAMPT in complex with NVP-LOD812==
+<StructureSection load='6atb' size='340' side='right' caption='[[6atb]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6atb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATB FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BWA:N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N-[(pyridin-3-yl)methyl]urea'>BWA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atb OCA], [http://pdbe.org/6atb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atb RCSB], [http://www.ebi.ac.uk/pdbsum/6atb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Thigale, S]]
+[[Category: Weihofen, W A]]
+[[Category: Complex]]
+[[Category: Transferase]]