Ricin: Difference between revisions
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'''Ricin''' is a potent cytotoxin that is synthesized in the endosperm cells of maturing seeds of the castor oil plant (''Ricinus communis'')<ref name="lord">PMID: 8119491</ref>. Ricin belongs to a small multi-gene family<ref name="montfort">PMID: 3558397</ref> that is composed of eight members. Ricin is classified as a type II heterodimeric Ribosome Inactivating Protein<ref name="lord" /> or RIPs. For toxins in Proteopedia see [[Toxins]]. | '''Ricin''' is a potent cytotoxin that is synthesized in the endosperm cells of maturing seeds of the castor oil plant (''Ricinus communis'')<ref name="lord">PMID: 8119491</ref>. Ricin belongs to a small multi-gene family<ref name="montfort">PMID: 3558397</ref> that is composed of eight members. Ricin is classified as a type II heterodimeric Ribosome Inactivating Protein<ref name="lord" /> or RIPs. For toxins in Proteopedia see [[Toxins]]. | ||
<StructureSection load='3rtj' size=' | <StructureSection load='3rtj' size='350' side='right' caption='Glycosylated ricin chain A (grey) and chain B (green) bound to dinucleotide APG (stick model) (PDB entry [[3rtj]])'> | ||
==Structure== | ==Structure== | ||
Ricin is a heterodimer that consists of a 32 kilodalton A chain glycoprotein (light blue) linked by a <scene name='38/382952/Disulfide_bond_between_subunit/3'>disulfide bond</scene> to a 32 kilodalton <scene name='Sandbox_BCMB402_Ricin/B_subunit/1'>B chain</scene> glycoprotein<ref name="montfort" /> (green). | Ricin is a heterodimer that consists of a 32 kilodalton A chain glycoprotein (light blue) linked by a <scene name='38/382952/Disulfide_bond_between_subunit/3'>disulfide bond</scene> to a 32 kilodalton <scene name='Sandbox_BCMB402_Ricin/B_subunit/1'>B chain</scene> glycoprotein<ref name="montfort" /> (green). | ||
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** [[1br5]], [[1br6]], [[4esi]], [[4huo]], [[4hup]], [[4hv3]], [[4hv7]], [[4mx1]], [[4mx5]] - RTA + pterin derivative<br /> | ** [[1br5]], [[1br6]], [[4esi]], [[4huo]], [[4hup]], [[4hv3]], [[4hv7]], [[4mx1]], [[4mx5]] - RTA + pterin derivative<br /> | ||
** [[3px9]] - RTA preproricin + furanylmethyl-carbamoyl-pterin<br /> | ** [[3px9]] - RTA preproricin + furanylmethyl-carbamoyl-pterin<br /> | ||
** [[3hio]] – RTA + tetranucleotide<br /> | ** [[3hio]] – RTA + tetranucleotide<br /> | ||
** [[3ej5]], [[1il5]] – RTA pyrimidine derivative<br /> | ** [[3ej5]], [[1il5]] – RTA pyrimidine derivative<br /> | ||
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** [[5ddz]] – RTA + ribosomal protein P2<br /> | ** [[5ddz]] – RTA + ribosomal protein P2<br /> | ||
** [[5gu4]] – RTA + peptide<br /> | ** [[5gu4]] – RTA + peptide<br /> | ||
** [[4kuc]], [[4lgp]], [[4lgr]], [[4lgs]], [[4lhj]], [[4lhq]], [[4z9k]], [[5boz]], [[5e1h]], [[5j56]], [[5j57]], [[5sv3]] – RTA + antibody<br /> | ** [[4kuc]], [[4lgp]], [[4lgr]], [[4lgs]], [[4lhj]], [[4lhq]], [[4z9k]], [[5boz]], [[5e1h]], [[5j56]], [[5j57]], [[5sv3]], [[5u4m]], [[5u4l]] – RTA + antibody<br /> | ||
* Ricin B chain (RTB) | * Ricin B chain (RTB) | ||
