SAM-dependent methyltransferase: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' scene='51/510230/Cv/3' caption='SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate [[3ou6]]'> | ||
== Function == | == Function == | ||
'''SAM-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids. SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation. About 120 members of the SDM family have been identified. They differ in their substrate specificity and the atom targeted for methylation (N, O, C, S)<ref>PMID:23180741</ref>. | '''SAM-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids. SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation. About 120 members of the SDM family have been identified. They differ in their substrate specificity and the atom targeted for methylation (N, O, C, S)<ref>PMID:23180741</ref>. | ||
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**[[4kif]], [[4kig]] – ShSDM + phenylpyruvate <br /> | **[[4kif]], [[4kig]] – ShSDM + phenylpyruvate <br /> | ||
**[[4m6x]], [[4m6y]], [[4m71]] – ShSDM (mutant) + SAH + methylphenylpyruvate <br /> | **[[4m6x]], [[4m6y]], [[4m71]] – ShSDM (mutant) + SAH + methylphenylpyruvate <br /> | ||
**[[5o4h]] – MmHCGC + SAM + pyridinol - Methanococcus maripaludis <br /> | |||
**[[5o4n]], [[5o4j]], [[5o4m]] – MmHCGC + SAH + pyridinol <br /> | |||
*SAM-dependent methyltransferase | *SAM-dependent methyltransferase | ||
