6g04: Difference between revisions

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'''Unreleased structure'''


The entry 6g04 is ON HOLD
==NMR Solution Structure of Yeast TSR2(1-152) in Complex with S26A(100-119)==
<StructureSection load='6g04' size='340' side='right' caption='[[6g04]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6g04]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G04 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g03|6g03]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g04 OCA], [http://pdbe.org/6g04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g04 RCSB], [http://www.ebi.ac.uk/pdbsum/6g04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g04 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TSR2_YEAST TSR2_YEAST]] Required for 20S pre-rRNA processing.<ref>PMID:12837249</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Disordered extensions at the termini and short internal insertions distinguish eukaryotic ribosomal proteins (r-proteins) from their anucleated archaeal counterparts. Here, we report an NMR structure of such a eukaryotic-specific segment (ESS) in the r-protein eS26 in complex with the escortin Tsr2. The structure reveals how ESS attracts Tsr2 specifically to importin:eS26 complexes entering the nucleus in order to trigger non-canonical RanGTP-independent disassembly. Tsr2 then sequesters the released eS26 and prevents rebinding to the importin, providing an alternative allosteric mechanism to terminate the process of nuclear import. Notably, a Diamond-Blackfan anemia-associated Tsr2 mutant protein is impaired in binding to ESS, unveiling a critical role for this interaction in human hematopoiesis. We propose that eS26-ESS and Tsr2 are components of a nuclear sorting system that co-evolved with the emergence of the nucleocytoplasmic barrier and transport carriers.


Authors: Michel, E., Schuetz, S., Damberger, F.F., Allain, F.H.-T., Panse, V.G.
Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2.,Schutz S, Michel E, Damberger FF, Oplova M, Pena C, Leitner A, Aebersold R, Allain FH, Panse VG Nat Commun. 2018 Sep 10;9(1):3669. doi: 10.1038/s41467-018-06160-x. PMID:30201955<ref>PMID:30201955</ref>


Description: NMR Solution Structure of Yeast TSR2(1-152) in Complex with S26A(100-119)
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Panse, V.G]]
<div class="pdbe-citations 6g04" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Allain, F H.T]]
[[Category: Damberger, F F]]
[[Category: Michel, E]]
[[Category: Panse, V G]]
[[Category: Schuetz, S]]
[[Category: Schuetz, S]]
[[Category: Allain, F.H.-T]]
[[Category: Alpha-helical protein]]
[[Category: Damberger, F.F]]
[[Category: Escortin]]
[[Category: Michel, E]]
[[Category: Eukaryotic specific segment]]
[[Category: Nuclear unloading factor]]
[[Category: Nucleus]]
[[Category: Ribosome maturation]]
[[Category: Transport of ribosomal protein s26]]
[[Category: Transport protein]]
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