Sorting nexin

spinqualitylabelsall models Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry 3dyt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sorting nexins (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association. The PX domain contains a phospholipid-binding motif. SNX 1 regulates trafficking in the endosome compartment. SNX 3 regulates neurite formation. SNX 5 regulates retrograde trafficking of transmembrane cargo receptors. SNX 7 regulates the survival of cells in embryonic liver. SNX 9 has a role in endocytosis. SNX 10 induces giant vacuoles in mammalian cells. SNX 11and SNX 17 regulate lysosomal degradation of plasma membrane. SNX 12 regulates BACE1-mediated APP processing . SNX 14 has a role in maintaining normal neuronal excitability. SNX 16 has a role in protein transport from early to late endosomes. SNX 22, SNX 24 and SNX 25 may have a role in intracellular trafficking. SNX 27 modulates synaptic plasticity. SNX 33 induces micronucleated phenotype and actin polymerization. Relevance SNX 2 is a potential marker of hyperfunctioning thyroid disorders.

3D structures of sorting nexin

Updated on 20-September-2018

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• Sorting nexin 1
  • 2i4k – hSNX PX domain - human - NMR
    
  • 4fzs – hSNX BAR domain
    
• Sorting nexin 3
  • 1ocs – ySNX PX domain – yeast
    
  • 1ocu – ySNX PX domain + phosphatidylinositol-3-phosphate
    
  • 2mxc – hSNX - NMR
    
  • 2yps – hSNX PX domain
    
  • 5f0j – hSNX PX domain + VPS26 + VPS35
    
  • 5f0l, 5f0m, 5f0p – hSNX + VPS26 + VPS35 + DMT1 peptide
    
• Sorting nexin 5
  • 3hpb, 3hpc – rSNX PX domain – rat
    
  • 5tgh, 5tgi, 5wy2 – hSNX PX domain + INCE
    
  • 5tp1 – mSNX PX domain + INCE
    
• Sorting nexin 7
  • 3iq2 – hSNX PX domain
    
• Sorting nexin 9
  • 2enm – SNX SH3 domain – mouse - NMR
    
  • 2rai, 2raj, 2rak, 3dyt, 3dyu – hSNX PX-BAR domain
    
  • 3lge – SNX residues 152-182 + aldolase – rabbit
    
• Sorting nexin 10
  • 4on3, 4pzg – hSNX residues 1-201
    
• Sorting nexin 11
  • 4ikb, 4ikd – hSNX PX domain
    
• Sorting nexin 12
  • 2csk – hSNX PX domain
    
• Sorting nexin 14
  • 4bgj, 4pqo, 4pqp – hSNX PX domain
    
• Sorting nexin 15
  • 6mbi, 6ecm – hSNX PX domain
    
• Sorting nexin 16
  • 5gw0, 5gw1 – hSNX PX-coiled coll domain
    
• Sorting nexin 17
  • 3fog, 3lui – hSNX PX domain
    
  • 4gxb, 4tkn – hSNX FERM domain + NPXY motif
    
• Sorting nexin 21
  • 4ymr – mSNX PX/TPR domain
    
• Sorting nexin 22
  • 2ett – hSNX PX domain - NMR
    
• Sorting nexin 23
  • 6ee0 – hSNX PX domain
    
• Sorting nexin 24
  • 4az9 – hSNX PX domain
    
• Sorting nexin 25
  • 5xdz – SNX PX domain - zebrafish
    
  • 5woe – hSNX Phox hiomology domain - NMR
    
• Sorting nexin 27
  • 3qdo, 3qe1 – rSNX PDZ domain/GIRK3 C terminal
    
  • 3qgl – rSNX PDZ domain + GIRK3 C terminal
    
  • 5elq – rSNX PDZ domain + DGKζ C terminal
    
  • 5em9, 5ema, 5emb, 4z8j – rSNX PDZ domain + PDZ-binding motif
    
  • 4p2a – rSNX PDZ domain + VPSA26
    
  • 4z8j – rSNX PDZ domain + parathyroid hormone receptor PDZ domain
    
  • 4has – hSNX PX domain
    
• Sorting nexin 33
  • 4akv – hSNX PH-BAR domain
    
• Sorting nexin
  • 3hpb, 3hpc – rSNX PX domain – rat
    

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Michal Harel, Alexander Berchansky