5zyp: Difference between revisions

Revision as of 07:58, 26 September 2018

Structure of the Yeast Ctr9/Paf1 complex

Structural highlights

5zyp is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	NI
NonStd Res:	MSE
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CTR9_YEAST] The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. In complex with PAF1, required for normal CLN1 and CLN2 G1 cyclin expression in late G1. Also has a role in chromosome segregation where it appears to be involved in microtubule placement.^[1] ^[2] ^[3] ^[4]

References

↑ Koch C, Wollmann P, Dahl M, Lottspeich F. A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast. Nucleic Acids Res. 1999 May 15;27(10):2126-34. PMID:10219085
↑ Porter SE, Penheiter KL, Jaehning JA. Separation of the Saccharomyces cerevisiae Paf1 complex from RNA polymerase II results in changes in its subnuclear localization. Eukaryot Cell. 2005 Jan;4(1):209-20. PMID:15643076 doi:https://dx.doi.org/10.1128/EC.4.1.209-220.2005
↑ Sheldon KE, Mauger DM, Arndt KM. A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation. Mol Cell. 2005 Oct 28;20(2):225-36. PMID:16246725 doi:S1097-2765(05)01568-6
↑ Foreman PK, Davis RW. CDP1, a novel Saccharomyces cerevisiae gene required for proper nuclear division and chromosome segregation. Genetics. 1996 Dec;144(4):1387-97. PMID:8978028

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OCA

[1] Koch C, Wollmann P, Dahl M, Lottspeich F. A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast. Nucleic Acids Res. 1999 May 15;27(10):2126-34. PMID:10219085

[2] Porter SE, Penheiter KL, Jaehning JA. Separation of the Saccharomyces cerevisiae Paf1 complex from RNA polymerase II results in changes in its subnuclear localization. Eukaryot Cell. 2005 Jan;4(1):209-20. PMID:15643076 doi:https://dx.doi.org/10.1128/EC.4.1.209-220.2005

[3] Sheldon KE, Mauger DM, Arndt KM. A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation. Mol Cell. 2005 Oct 28;20(2):225-36. PMID:16246725 doi:S1097-2765(05)01568-6

[4] Foreman PK, Davis RW. CDP1, a novel Saccharomyces cerevisiae gene required for proper nuclear division and chromosome segregation. Genetics. 1996 Dec;144(4):1387-97. PMID:8978028

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5zyp is ON HOLD  until Paper Publication
+==Structure of the Yeast Ctr9/Paf1 complex==
+<StructureSection load='5zyp' size='340' side='right' caption='[[5zyp]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
-Authors: Xie, Y., Zheng, M., Zhou, H., Long, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5zyp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZYP FirstGlance]. <br>
-Description: Structure of the Yeast Ctr9/Paf1 complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zyp OCA], [http://pdbe.org/5zyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zyp RCSB], [http://www.ebi.ac.uk/pdbsum/5zyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zyp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CTR9_YEAST CTR9_YEAST]] The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. In complex with PAF1, required for normal CLN1 and CLN2 G1 cyclin expression in late G1. Also has a role in chromosome segregation where it appears to be involved in microtubule placement.<ref>PMID:10219085</ref> <ref>PMID:15643076</ref> <ref>PMID:16246725</ref> <ref>PMID:8978028</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Long, J]]
+[[Category: Xie, Y]]
+[[Category: Zheng, M]]
 [[Category: Zhou, H]]
-[[Category: Zheng, M]]
+[[Category: Complex]]
-[[Category: Xie, Y]]
+[[Category: Tpr]]
+[[Category: Transciption]]
+[[Category: Transcription]]

5zyp: Difference between revisions

Revision as of 07:58, 26 September 2018

Structure of the Yeast Ctr9/Paf1 complex

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Function

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