2wbw: Difference between revisions

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==Ad37 fibre head in complex with CAR D1 and sialic acid==

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</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbw OCA], [http://pdbe.org/2wbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbw RCSB], [http://www.ebi.ac.uk/pdbsum/2wbw PDBsum]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbw OCA], [http://pdbe.org/2wbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbw RCSB], [http://www.ebi.ac.uk/pdbsum/2wbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbw ProSAT]</td></tr>

</table>

~~== Function ==~~

[[http://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbw_consurf.spt"</scriptWhenChecked>

<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbw_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

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[[Category: Ad37]]

[[Category: Adenovirus]]

[[Category: Alternative splicing]]

[[Category: Car]]

[[Category: Cell adhesion]]

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[[Category: Phosphoprotein]]

[[Category: Phosphorylation]]

[[Category: Polymorphism]]

[[Category: Receptor]]

[[Category: Red blood cell]]

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 ==Ad37 fibre head in complex with CAR D1 and sialic acid==
 <StructureSection load='2wbw' size='340' side='right' caption='[[2wbw]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w9l|2w9l]], [[2j12|2j12]], [[1eaj|1eaj]], [[1p69|1p69]], [[1jew|1jew]], [[1kac|1kac]], [[1rsf|1rsf]], [[1p6a|1p6a]], [[1f5w|1f5w]], [[2j1k|2j1k]], [[2wbv|2wbv]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbw OCA], [http://pdbe.org/2wbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbw RCSB], [http://www.ebi.ac.uk/pdbsum/2wbw PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbw OCA], [http://pdbe.org/2wbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbw RCSB], [http://www.ebi.ac.uk/pdbsum/2wbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbw ProSAT]</span></td></tr>
 </table>
-== Function ==
-[[http://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbw_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbw_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 52: / Line 51: @@
 [[Category: Ad37]]
 [[Category: Adenovirus]]
+[[Category: Alternative splicing]]
 [[Category: Car]]
 [[Category: Cell adhesion]]
@@ Line 70: / Line 70: @@
 [[Category: Phosphoprotein]]
 [[Category: Phosphorylation]]
+[[Category: Polymorphism]]
 [[Category: Receptor]]
 [[Category: Red blood cell]]