Tryptophan synthase: Difference between revisions

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<StructureSection load='' size='400' side='right' caption='Tryptophan synthase α subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]' scene='52/525189/Cv/5'>
<StructureSection load='' size='350' side='right' caption='Tryptophan synthase α subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]' scene='52/525189/Cv/5'>
== Function ==
== Function ==
'''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan<ref>PMID:11893063</ref>.  TrpS '''α subunit''' catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP).  The '''β subunit''' catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine.  The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits.   
'''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan<ref>PMID:11893063</ref>.  TrpS '''α subunit''' catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP).  The '''β subunit''' catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine.  The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits.   
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**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br />
**[[2dh6]] - EcTrpS β subunit]] - ''Escherichia coli''<br />
**[[2dh6]] - EcTrpS β subunit - ''Escherichia coli''<br />
**[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br />
**[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br />
**[[1v8z]] - PfTrpS β subunit <br />
**[[1v8z]] - PfTrpS β1 subunit <br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br />
**[[4qys]] - TrpS β subunit – ''Sulfolobus solfataricus''<br />
**[[4qys]] - SsTrpS β2 subunit – ''Sulfolobus solfataricus''<br />


*Tryptophan synthase β complex
*Tryptophan synthase β complex


**[[2dh5]] - EcTrpS β subunit + PLP<br />
**[[2dh5]] - EcTrpS β subunit + PLP<br />
**[[5dvz]] - PfTrpS β subunit + PLP derivative <br />
**[[6eqn]] - SsTrpS β2 subunit + PLP<br />
**[[5dw0]] - PfTrpS β subunit + Ser derivative <br />
**[[5dvz]] - PfTrpS β1 subunit + PLP derivative <br />
**[[5dw3]] - PfTrpS β subunit + PLP derivative + Trp<br />
**[[6am7]], [[6amc]], [[6cuv]] - PfTrpS β1 subunit (mutant) + PLP derivative <br />
**[[5t6m]] - PfTrpS β subunit + PLP derivative + Trp derivative<br />
**[[5dw0]] - PfTrpS β1 subunit + Ser derivative <br />
**[[5vm5]] - PfTrpS β subunit + PLP derivative + Ser derivative<br />
**[[5dw3]] - PfTrpS β1 subunit + PLP derivative + Trp<br />
**[[5ixj]] - PfTrpS β subunit + PLP derivative + Thr<br />
**[[6am8]], [[6ami]] - PfTrpS β1 subunit (mutant) + PLP derivative + Trp<br />
**[[5t6m]] - PfTrpS β1 subunit + PLP derivative + Trp derivative<br />
**[[5vm5]] - PfTrpS β1 subunit + PLP derivative + Ser derivative<br />
**[[5ixj]] - PfTrpS β1 subunit + PLP derivative + Thr<br />
**[[6am9]], [[6amh]] - PfTrpS β1 subunit (mutant) + PLP-Ser derivative <br />
**[[6cut]] - PfTrpS β1 subunit (mutant) + Trp analog <br />
**[[6cuz]] - PfTrpS β1 subunit (mutant) + PLP derivative + ethylserine<br />


*'''Tryptophan synthase α+β subunits'''
*'''Tryptophan synthase α+β subunits'''
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**[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br />
**[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br />
**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br />
**[[6du1]], [[6dua]], [[6dwe]], [[6e9p]] - MtTrpS α + β + malonate + inhibitor + PLP derivative<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 17:07, 28 September 2018

Tryptophan synthaseα subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) 1wbj

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3D structures of tryptophan synthase

Updated on 28-September-2018

    • 1ttp, 1ttq, 1bks, 2wsy, 1kfk - StTrpS α + β + PLP – Salmonella typhimurium
    • 1a5a, 1k8x - StTrpS α (mutant) + β + PLP
    • 1k7x, 2j9z - StTrpS α + β (mutant) + PLP
    • 2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
    • 1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
    • 1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
    • 2j9y - StTrpS α + β (mutant) + enoic acid derivative
    • 3pr2, 4hn4, 4hpj, 4hpx, 4ht3, 4kkx - StTrpS α + β + inhibitor
    • 5kzm - TrpS α + β + PLP derivative – Francisella tularensis
    • 5kin - TrpS α + β + PLP derivative – Streptococcus pneumoniae
    • 5e0k - PfTrpS α + β + PLP derivative
    • 5ocw, 5tcg, 5tci, 5tcj - MtTrpS α + β + inhibitor
    • 5tcf - MtTrpS α + β + PLP derivative
    • 5tch - MtTrpS α + β (mutant) + PLP derivative
    • 5e0k - PfTrpS α + β + PLP derivative
  • Tryptophan synthase α+β ternary complex with PLP and inhibitor
  • Tryptophan synthase α+β ternary complex with PLP and IGP derivatives
    • 1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
    • 1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
    • 1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
    • 1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
    • 1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
    • 1qop - StTrpS α + β + IGP analog + PLP
    • 2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog
  • Tryptophan synthase α+β ternary complex with PLP and G3P derivatives
    • 1wbj - StTrpS α + β + G3P + PLP
    • 2j9x - StTrpS α + β + G3P + acrylic acid derivative
    • 1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
    • 1tjp - StTrpS α + β + G3P derivative + PLP
    • 2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P
    • 1ubs - StTrpS α (mutant) + β (mutant) + serine + PLP
  • Tryptophan synthase α+β quaternary complex
    • 1a5s - StTrpS α + β + serine + inhibitor + PLP
    • 5cgq - StTrpS α + β + Trp + inhibitor + PLP
    • 3cep - StTrpS α + β + G3P + indoline + PLP
    • 6du1, 6dua, 6dwe, 6e9p - MtTrpS α + β + malonate + inhibitor + PLP derivative

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Amer Ali, Joel L. Sussman

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