6dwn: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6dwn is ~~ON HOLD until Paper Publication~~

==Structure of Human Cytochrome P450 1A1 with Erlotinib==

~~Authors~~: ~~Bart~~, A.G., ~~Scott~~, E.E.

== Structural highlights ==

<table><tr><td colspan='2'>[[6dwn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DWN OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DWN FirstGlance].

~~Description~~: ~~Structure~~ of ~~Human Cytochrome P450 1A1 with Erlotinib~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=AQ4:[6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE'>AQ4</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </td></tr>

[[Category: Scott, E.E]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dwn OCA], [http://pdbe.org/6dwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dwn RCSB], [http://www.ebi.ac.uk/pdbsum/6dwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dwn ProSAT]</td></tr>

[[Category: ~~Bart, A.G~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CP1A1_HUMAN CP1A1_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

__TOC__

</StructureSection>

[[Category: Unspecific monooxygenase]]

[[Category: Bart, A G]]

[[Category: Scott, E E]]

[[Category: Ligand]]

[[Category: Oxidoreductase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6dwn is ON HOLD  until Paper Publication
+==Structure of Human Cytochrome P450 1A1 with Erlotinib==
+<StructureSection load='6dwn' size='340' side='right' caption='[[6dwn]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Bart, A.G., Scott, E.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6dwn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DWN FirstGlance]. <br>
-Description: Structure of Human Cytochrome P450 1A1 with Erlotinib
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQ4:[6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE'>AQ4</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
-[[Category: Scott, E.E]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dwn OCA], [http://pdbe.org/6dwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dwn RCSB], [http://www.ebi.ac.uk/pdbsum/6dwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dwn ProSAT]</span></td></tr>
-[[Category: Bart, A.G]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CP1A1_HUMAN CP1A1_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
+__TOC__
+</StructureSection>
+[[Category: Unspecific monooxygenase]]
+[[Category: Bart, A G]]
+[[Category: Scott, E E]]
+[[Category: Ligand]]
+[[Category: Oxidoreductase]]