Virion infectivity factor: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='HIV-1 virion infectivity factor (deep sky blue) complex with human elongin-B (green) and elongin-C (pink) (PDB code [[2ma9]])' scene='75/750233/Cv/1'> | ||
== Function == | == Function == | ||
Virion infectivity factor (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. <scene name='75/750233/Cv/3'>Interactions between HIV-1 virion infectivity factor and human elongin-B and elongin-C</scene>. | '''Virion infectivity factor''' (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. <scene name='75/750233/Cv/3'>Interactions between HIV-1 virion infectivity factor and human elongin-B and elongin-C</scene>. | ||
For details see [[HIV and accessory proteins]] | For details see [[HIV and accessory proteins]] | ||
