Virus protease: Difference between revisions

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Michal Harel (talk | contribs)
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<StructureSection load='' size='350' side='right' caption='HIV-1 protease dimer complex with tert-butylcarbonate (PDB entry [[1odw]])' scene='44/443708/Cv/2'>


'''Virus proteases''' include HIV protease, XMRV protease, retropepsin.
<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the  virus<ref>PMID:12475203</ref>. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion.  HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.  
__TOC__
*<scene name='44/443708/Cv/3'>HIV-1 protease dimer complex with inhibitor tert-butylcarbonate </scene>.
== Function ==
*<scene name='44/443708/Cv/5'>Inhibitor BMS-182193 binding site</scene>.
   
'''3C protease''' (3CP) is a virus cysteine protease which has essential role in viral replication.  3CP cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref>  For more details on Foot and Mouth Disease virus 3C protease see [[FMDV 3C]].
 
== Disease ==
 
3CP is an attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.  Coxsakievirus causes the human diseases myocarditis and pericarditis.
 
== Structural highlights ==
 
3CP - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.
 
See also<br />
See also<br />


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*'''Foot-and-Mouth Disease virus protease'''
*'''Foot-and-Mouth Disease virus protease'''


**[[2bhg]] – FMDV – Foot-and-mouth disease virus  
**[[2bhg]] – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus  


*'''Infectious Bronchitis virus protease'''
*'''Infectious Bronchitis virus protease'''
Retrieved from "https://proteopedia.org/Virus_protease"