User:Wally Novak/Sandbox Whitaker: Difference between revisions
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==U5 snRNP== | ==U5 snRNP== | ||
<StructureSection load='1stp' size='340' side='right' caption=' | <StructureSection load='1stp' size='340' side='right' caption='Human Spliceosomal Protein U5-15kD'> | ||
==Function== | ==Function== | ||
===General Overview=== | ===General Overview=== | ||
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The U5 snRNA interacts directly with the 5’ exon before the first step of splicing and with the 5’ and 3’ exons following the first step of splicing <ref name="Keefe">PMID:9430647</ref>. These U5–exon interactions are essential for tethering and aligning the exons for ligation during the second step of splicing <ref name="Keefe" />. | The U5 snRNA interacts directly with the 5’ exon before the first step of splicing and with the 5’ and 3’ exons following the first step of splicing <ref name="Keefe">PMID:9430647</ref>. These U5–exon interactions are essential for tethering and aligning the exons for ligation during the second step of splicing <ref name="Keefe" />. | ||
===Brr2=== | ===Brr2=== | ||
<Structure load='3hib' size='400' frame='true' align='right' caption='Brr2="/> | |||
Brr2 is an ATPase required for unwinding U4/U6 base-pairing before the first step of splicing and for unwinding U2/U6 base-pairing after the second step of splicing <ref>PMID:20659012</ref>. These conformational changes catalyzed by Brr2 are essential for the progression of the spliceosome cycle. | Brr2 is an ATPase required for unwinding U4/U6 base-pairing before the first step of splicing and for unwinding U2/U6 base-pairing after the second step of splicing <ref>PMID:20659012</ref>. These conformational changes catalyzed by Brr2 are essential for the progression of the spliceosome cycle. | ||
===Prp8=== | ===Prp8=== | ||
