6gbr: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6gbr is ~~ON HOLD until Paper Publication~~

==Crystal Structure of the oligomerization domain of VP35 from Reston virus, mercury derivative==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6gbr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBR FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbr OCA], [http://pdbe.org/6gbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbr RCSB], [http://www.ebi.ac.uk/pdbsum/6gbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbr ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).

__TOC__

</StructureSection>

[[Category: Baumeister, W]]

[[Category: Bracher, A]]

[[Category: Nagy, I]]

[[Category: Orsini, M]]

[[Category: Weyher-Stingl, E]]

[[Category: Zinzula, L]]

[[Category: Coiled-coil]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6gbr is ON HOLD  until Paper Publication
+==Crystal Structure of the oligomerization domain of VP35 from Reston virus, mercury derivative==
+<StructureSection load='6gbr' size='340' side='right' caption='[[6gbr]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6gbr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBR FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbr OCA], [http://pdbe.org/6gbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbr RCSB], [http://www.ebi.ac.uk/pdbsum/6gbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Baumeister, W]]
+[[Category: Bracher, A]]
+[[Category: Nagy, I]]
+[[Category: Orsini, M]]
+[[Category: Weyher-Stingl, E]]
+[[Category: Zinzula, L]]
+[[Category: Coiled-coil]]
+[[Category: Viral protein]]