6b9a: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6b9a is ~~ON HOLD~~ ~~until Paper Publication~~

==Hsp90-alpha N-domain bound to NPCA==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6b9a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B9A FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PA7:N-PROPYL+CARBOXYAMIDO+ADENOSINE'>PA7</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b9a OCA], [http://pdbe.org/6b9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b9a RCSB], [http://www.ebi.ac.uk/pdbsum/6b9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b9a ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gewirth, D T]]

[[Category: Huck, J D]]

[[Category: Chaperone]]

[[Category: Chaperone-inhibitor complex]]

[[Category: Hsp90]]

[[Category: Inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6b9a is ON HOLD  until Paper Publication
+==Hsp90-alpha N-domain bound to NPCA==
+<StructureSection load='6b9a' size='340' side='right' caption='[[6b9a]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6b9a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B9A FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PA7:N-PROPYL+CARBOXYAMIDO+ADENOSINE'>PA7</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b9a OCA], [http://pdbe.org/6b9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b9a RCSB], [http://www.ebi.ac.uk/pdbsum/6b9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b9a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gewirth, D T]]
+[[Category: Huck, J D]]
+[[Category: Chaperone]]
+[[Category: Chaperone-inhibitor complex]]
+[[Category: Hsp90]]
+[[Category: Inhibitor]]