6cac: Difference between revisions
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==Crystal structure of NDM-1 metallo-beta-lactamase harboring an insertion of a Pro residue in L3 loop== | |||
<StructureSection load='6cac' size='340' side='right' caption='[[6cac]], [[Resolution|resolution]] 1.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cac]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAC FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3spu|3spu]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cac OCA], [http://pdbe.org/6cac PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cac RCSB], [http://www.ebi.ac.uk/pdbsum/6cac PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cac ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Alzari, P M]] | |||
[[Category: Bonomo, R]] | [[Category: Bonomo, R]] | ||
[[Category: Giannini, E]] | |||
[[Category: Llarrull, L]] | |||
[[Category: Mojica, M]] | [[Category: Mojica, M]] | ||
[[Category: Palacios, A]] | [[Category: Palacios, A]] | ||
[[Category: Vila, A]] | [[Category: Vila, A]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: Ndm-1]] | |||
[[Category: Zn-containing protein]] | |||
Revision as of 07:55, 17 October 2018
Crystal structure of NDM-1 metallo-beta-lactamase harboring an insertion of a Pro residue in L3 loop
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