2rmj: Difference between revisions
New page: left|200px {{Structure |PDB= 2rmj |SIZE=350|CAPTION= <scene name='initialview01'>2rmj</scene> |SITE= |LIGAND= |ACTIVITY= |GENE= DDX58 ([http://www.ncbi.nlm.nih.gov/... |
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|GENE= DDX58 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= DDX58 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |DOMAIN= | ||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmj OCA], [http://www.ebi.ac.uk/pdbsum/2rmj PDBsum | |RELATEDENTRY= | ||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmj OCA], [http://www.ebi.ac.uk/pdbsum/2rmj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rmj RCSB]</span> | |||
}} | }} | ||
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[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:02:02 2008'' | ||
Revision as of 02:02, 31 March 2008
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| 2rmj | |||||||||||||
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| Gene: | DDX58 (Homo sapiens) | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Solution structure of RIG-I C-terminal domain
Overview
A DExD/H protein, RIG-I, is critical in innate antiviral responses by sensing viral RNA. Here we show that RIG-I recognizes two distinct viral RNA patterns: double-stranded (ds) and 5'ppp single-stranded (ss) RNA. The binding of RIG-I with dsRNA or 5'ppp ssRNA in the presence of ATP produces a common structure, as suggested by protease digestion. Further analyses demonstrated that the C-terminal domain of RIG-I (CTD) recognizes these RNA patterns and CTD coincides with the autorepression domain. Structural analysis of CTD by NMR spectroscopy in conjunction with mutagenesis revealed that the basic surface of CTD with a characteristic cleft interacts with RIG-I ligands. Our results suggest that the bipartite structure of CTD regulates RIG-I on encountering viral RNA patterns.
About this Structure
2RMJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses., Takahasi K, Yoneyama M, Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T, Mol Cell. 2008 Feb 29;29(4):428-40. Epub 2008 Jan 31. PMID:18242112
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Fujita, T.
- Hirai, R.
- Inagaki, F.
- Jr., M Gale.
- Narita, R.
- Nihishori, T.
- Takahasi, K.
- Yoneyama, M.
- Alternative splicing
- Antiviral defense
- Atp-binding
- Cytoplasm
- Helicase
- Hydrolase
- Immune response
- Innate immunity
- Interferon induction
- Nucleotide-binding
- Polymorphism
- Rna binding protein
- Rna-binding
- Ubl conjugation
