6cwv: Difference between revisions
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==Protein Tyrosine Phosphatase 1B A122S mutant== | |||
<StructureSection load='6cwv' size='340' side='right' caption='[[6cwv]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cwv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CWV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cwv OCA], [http://pdbe.org/6cwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cwv RCSB], [http://www.ebi.ac.uk/pdbsum/6cwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cwv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Protein-tyrosine-phosphatase]] | |||
[[Category: Fox, J M]] | |||
[[Category: Hjortness, M]] | |||
[[Category: Sankaran, B]] | |||
[[Category: Zwart, P]] | |||
[[Category: Cancer]] | |||
[[Category: Diabetes]] | |||
[[Category: Hydrolase]] | |||
[[Category: Insulin signaling]] | |||
[[Category: Signaling]] | |||
Revision as of 05:52, 24 October 2018
Protein Tyrosine Phosphatase 1B A122S mutant
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