6ejx: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6ejx is ON HOLD~~

==The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function==

~~Authors: Emsley, J., Saleem, M.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6ejx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJX FirstGlance]. <br>

~~Description:~~ The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejx OCA], [http://pdbe.org/6ejx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejx RCSB], [http://www.ebi.ac.uk/pdbsum/6ejx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejx ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GP1BA_MOUSE GP1BA_MOUSE]] GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

__TOC__

</StructureSection>

[[Category: Emsley, J]]

[[Category: Saleem, M]]

[[Category: ~~Emsley, J~~]]

[[Category: Blood clotting]]

[[Category: Gp1balpha]]

[[Category: Mac-1]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ejx is ON HOLD
+==The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function==
+<StructureSection load='6ejx' size='340' side='right' caption='[[6ejx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Emsley, J., Saleem, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ejx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EJX FirstGlance]. <br>
-Description: The metal ion-dependent adhesion site (MIDAS) of the alphaMbeta2 integrin Mac-1 I-domain promiscuously and competitively binds multiple ligands in the regulation of Leukocyte function
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ejx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ejx OCA], [http://pdbe.org/6ejx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ejx RCSB], [http://www.ebi.ac.uk/pdbsum/6ejx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ejx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GP1BA_MOUSE GP1BA_MOUSE]] GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
+__TOC__
+</StructureSection>
+[[Category: Emsley, J]]
 [[Category: Saleem, M]]
-[[Category: Emsley, J]]
+[[Category: Blood clotting]]
+[[Category: Gp1balpha]]
+[[Category: Mac-1]]