6e7d: Difference between revisions

Revision as of 05:54, 24 October 2018

Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b

Structural highlights

6e7d is a 24 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	NAG, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CLC2D_MOUSE] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).^[1] ^[2] ^[3] ^[4] ^[5] [KRBBB_MOUSE] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.^[6] ^[7]

References

↑ Zhou H, Kartsogiannis V, Hu YS, Elliott J, Quinn JM, McKinstry WJ, Gillespie MT, Ng KW. A novel osteoblast-derived C-type lectin that inhibits osteoclast formation. J Biol Chem. 2001 May 4;276(18):14916-23. Epub 2001 Feb 13. PMID:11278931 doi:https://dx.doi.org/10.1074/jbc.M011554200
↑ Zhou H, Kartsogiannis V, Quinn JM, Ly C, Gange C, Elliott J, Ng KW, Gillespie MT. Osteoclast inhibitory lectin, a family of new osteoclast inhibitors. J Biol Chem. 2002 Dec 13;277(50):48808-15. Epub 2002 Oct 8. PMID:12374791 doi:https://dx.doi.org/10.1074/jbc.M209059200
↑ Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3527-32. Epub 2004 Feb 27. PMID:14990792 doi:https://dx.doi.org/10.1073/pnas.0308304101
↑ Gange CT, Quinn JM, Zhou H, Kartsogiannis V, Gillespie MT, Ng KW. Characterization of sugar binding by osteoclast inhibitory lectin. J Biol Chem. 2004 Jul 9;279(28):29043-9. Epub 2004 May 3. PMID:15123656 doi:https://dx.doi.org/10.1074/jbc.M312518200
↑ Carlyle JR, Mesci A, Ljutic B, Belanger S, Tai LH, Rousselle E, Troke AD, Proteau MF, Makrigiannis AP. Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J Immunol. 2006 Jun 15;176(12):7511-24. PMID:16751398
↑ Iizuka K, Naidenko OV, Plougastel BF, Fremont DH, Yokoyama WM. Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol. 2003 Aug;4(8):801-7. Epub 2003 Jul 13. PMID:12858173 doi:https://dx.doi.org/10.1038/ni954
↑ Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3527-32. Epub 2004 Feb 27. PMID:14990792 doi:https://dx.doi.org/10.1073/pnas.0308304101

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OCA

[1] Zhou H, Kartsogiannis V, Hu YS, Elliott J, Quinn JM, McKinstry WJ, Gillespie MT, Ng KW. A novel osteoblast-derived C-type lectin that inhibits osteoclast formation. J Biol Chem. 2001 May 4;276(18):14916-23. Epub 2001 Feb 13. PMID:11278931 doi:https://dx.doi.org/10.1074/jbc.M011554200

[2] Zhou H, Kartsogiannis V, Quinn JM, Ly C, Gange C, Elliott J, Ng KW, Gillespie MT. Osteoclast inhibitory lectin, a family of new osteoclast inhibitors. J Biol Chem. 2002 Dec 13;277(50):48808-15. Epub 2002 Oct 8. PMID:12374791 doi:https://dx.doi.org/10.1074/jbc.M209059200

[3] Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3527-32. Epub 2004 Feb 27. PMID:14990792 doi:https://dx.doi.org/10.1073/pnas.0308304101

[4] Gange CT, Quinn JM, Zhou H, Kartsogiannis V, Gillespie MT, Ng KW. Characterization of sugar binding by osteoclast inhibitory lectin. J Biol Chem. 2004 Jul 9;279(28):29043-9. Epub 2004 May 3. PMID:15123656 doi:https://dx.doi.org/10.1074/jbc.M312518200

[5] Carlyle JR, Mesci A, Ljutic B, Belanger S, Tai LH, Rousselle E, Troke AD, Proteau MF, Makrigiannis AP. Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. J Immunol. 2006 Jun 15;176(12):7511-24. PMID:16751398

[6] Iizuka K, Naidenko OV, Plougastel BF, Fremont DH, Yokoyama WM. Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol. 2003 Aug;4(8):801-7. Epub 2003 Jul 13. PMID:12858173 doi:https://dx.doi.org/10.1038/ni954

[7] Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3527-32. Epub 2004 Feb 27. PMID:14990792 doi:https://dx.doi.org/10.1073/pnas.0308304101

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6e7d is ON HOLD  until Paper Publication
+==Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b==
+<StructureSection load='6e7d' size='340' side='right' caption='[[6e7d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e7d]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E7D FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7d OCA], [http://pdbe.org/6e7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e7d RCSB], [http://www.ebi.ac.uk/pdbsum/6e7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CLC2D_MOUSE CLC2D_MOUSE]] Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis (PubMed:14990792, PubMed:16751398). Inhibits osteoclast formation (PubMed:11278931, PubMed:12374791). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656).<ref>PMID:11278931</ref> <ref>PMID:12374791</ref> <ref>PMID:14990792</ref> <ref>PMID:15123656</ref> <ref>PMID:16751398</ref>  [[http://www.uniprot.org/uniprot/KRBBB_MOUSE KRBBB_MOUSE]] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent "missing-self" recognition of allografts, tumor cells and virus-infected cells.<ref>PMID:12858173</ref> <ref>PMID:14990792</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Balaji, G R]]
+[[Category: Berry, R]]
+[[Category: Rossjohn, J]]
+[[Category: C-type lectin related ligand]]
+[[Category: Immune complex]]
+[[Category: Immune system]]
+[[Category: Innate immunity]]
+[[Category: Natural killer cell receptor]]

6e7d: Difference between revisions

Revision as of 05:54, 24 October 2018

Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b

Structural highlights

Function

References

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