6eq4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6eq4 is ~~ON HOLD until Paper Publication~~

==MTH1 in complex with fragment 8==

~~Authors~~: ~~Wiedmer~~, L., ~~Sledz~~, P., ~~Caflisch~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[6eq4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ4 FirstGlance]. <br>

~~Description: MTH1 in complex with fragment 8~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSW:4-(3-fluoranylpyridin-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine'>BSW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq4 OCA], [http://pdbe.org/6eq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq4 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq4 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Caflisch, A]]

[[Category: Sledz, P]]

[[Category: Wiedmer, L]]

[[Category: Complex]]

[[Category: Dna repair]]

[[Category: Fragment]]

[[Category: Hydrolase]]

[[Category: Inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6eq4 is ON HOLD  until Paper Publication
+==MTH1 in complex with fragment 8==
+<StructureSection load='6eq4' size='340' side='right' caption='[[6eq4]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-Authors: Wiedmer, L., Sledz, P., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6eq4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ4 FirstGlance]. <br>
-Description: MTH1 in complex with fragment 8
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSW:4-(3-fluoranylpyridin-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine'>BSW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq4 OCA], [http://pdbe.org/6eq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq4 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Caflisch, A]]
 [[Category: Sledz, P]]
 [[Category: Wiedmer, L]]
+[[Category: Complex]]
+[[Category: Dna repair]]
+[[Category: Fragment]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor]]