6g0y: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==X-ray structure of M-21 protein complex== | |||
<StructureSection load='6g0y' size='340' side='right' caption='[[6g0y]], [[Resolution|resolution]] 2.42Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6g0y]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G0Y FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c3b|4c3b]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g0y OCA], [http://pdbe.org/6g0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g0y RCSB], [http://www.ebi.ac.uk/pdbsum/6g0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g0y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/M21_HRSVA M21_HRSVA]] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.<ref>PMID:8552680</ref> <ref>PMID:9420254</ref> <ref>PMID:10364337</ref> [[http://www.uniprot.org/uniprot/PHOSP_HRSVA PHOSP_HRSVA]] Acts as a cofactor that serves both to stabilize the protein L and to place the polymerase complex on the N:RNA template. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Barr, J]] | [[Category: Barr, J]] | ||
[[Category: Edwards, T | [[Category: Edwards, T A]] | ||
[[Category: Antitermination]] | |||
[[Category: Hrsv]] | |||
[[Category: Replication]] | |||
[[Category: Transcription]] | |||
[[Category: Viral protein]] | |||
Revision as of 08:19, 14 November 2018
X-ray structure of M-21 protein complex
| ||||||||||||
