Syntaxin: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Syntaxin''' (Stx) are membrane-integrated proteins that are instru... |
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<StructureSection load='3rk2' size='340' side='right' caption='Caption for this structure' scene=''> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of | '''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor<ref>PMID:26903802</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
