5yvo: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5yvo is ~~ON HOLD until Paper Publication~~

==Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor==

~~Authors~~: ~~Saisawang~~, C., ~~Ketterman~~, A., ~~Wongsantichon~~, J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5yvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVO OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YVO FirstGlance].

~~Description~~: Human ~~Glutathione Transferase Omega1 covalently bound to ML175 inhibitor~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLX:N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide'>MLX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">GSTO1, GSTTLP28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvo OCA], [http://pdbe.org/5yvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvo RCSB], [http://www.ebi.ac.uk/pdbsum/5yvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvo ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN]] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Human]]

[[Category: Ketterman, A]]

[[Category: Saisawang, C]]

[[Category: Wongsantichon, J]]

[[Category: ~~Saisawang, C~~]]

[[Category: Allosteric]]

[[Category: ~~Ketterman, A~~]]

[[Category: Gst]]

[[Category: Inhibitor]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yvo is ON HOLD  until Paper Publication
+==Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor==
+<StructureSection load='5yvo' size='340' side='right' caption='[[5yvo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Saisawang, C., Ketterman, A., Wongsantichon, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YVO FirstGlance]. <br>
-Description: Human Glutathione Transferase Omega1 covalently bound to ML175 inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLX:N-{3-[(2-chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide'>MLX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GSTO1, GSTTLP28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvo OCA], [http://pdbe.org/5yvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvo RCSB], [http://www.ebi.ac.uk/pdbsum/5yvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN]] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Ketterman, A]]
+[[Category: Saisawang, C]]
 [[Category: Wongsantichon, J]]
-[[Category: Saisawang, C]]
+[[Category: Allosteric]]
-[[Category: Ketterman, A]]
+[[Category: Gst]]
+[[Category: Inhibitor]]
+[[Category: Transferase]]