6bop: Difference between revisions
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==Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus== | |||
<StructureSection load='6bop' size='340' side='right' caption='[[6bop]], [[Resolution|resolution]] 2.71Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bop]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfm Aspfm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOP FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mcsA, cit1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=746128 ASPFM])</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bop OCA], [http://pdbe.org/6bop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bop RCSB], [http://www.ebi.ac.uk/pdbsum/6bop PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bop ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PRPC_ASPFM PRPC_ASPFM]] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.<ref>PMID:16008561</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aspfm]] | |||
[[Category: Chruszcz, M]] | [[Category: Chruszcz, M]] | ||
[[Category: Schlachter, C]] | [[Category: Schlachter, C]] | ||
[[Category: 2-methylcitrate synthase]] | |||
[[Category: Citrate synthase]] | |||
[[Category: Mcsa]] | |||
[[Category: Transferase]] | |||
Revision as of 20:24, 2 December 2018
Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus
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