6bqi: Difference between revisions
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==Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action== | |||
<StructureSection load='6bqi' size='340' side='right' caption='[[6bqi]], [[NMR_Ensembles_of_Models | 3 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bqi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQI FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YIH1, YCR059C, YCR59C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqi OCA], [http://pdbe.org/6bqi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqi RCSB], [http://www.ebi.ac.uk/pdbsum/6bqi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqi ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/YIH1_YEAST YIH1_YEAST]] Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis (PubMed:15126500, PubMed:15937339, PubMed:24333428). In normal conditions, it resides in a actin complex and has no activity (PubMed:15126500).<ref>PMID:15126500</ref> <ref>PMID:15937339</ref> <ref>PMID:24333428</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Baker's yeast]] | |||
[[Category: Edwards, P J.B]] | |||
[[Category: Goroncy, A K]] | |||
[[Category: Harjes, E]] | |||
[[Category: Jameson, G B]] | |||
[[Category: Loo, T]] | |||
[[Category: Norris, G E]] | |||
[[Category: Sax]] | |||
[[Category: Translation]] | |||
[[Category: Translational regulation]] | |||
Revision as of 20:25, 2 December 2018
Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action
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