Sandbox Reserved 1471: Difference between revisions
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== Background == | == Background == | ||
Cyclooxygenases are enzymes that catalyze the transformation of arachidonic acid into prostaglandins, prostacyclins, and thromboxanes.<ref name="Orlando">PMID:27710942</ref> Another name for cyclooxygenases is prostaglandin H2 synthase. There are two names because there are two catalytic activities: cyclooxygenase and peroxidase. The abbreviation for cyclooxygenase and prostaglandin H2 synthase is COX and PGHS respectively and can be used interchangeably. There are two types of cyclooxygenases: COX-1 and COX-2. COX-1 is responsible for platelet aggregation and gastric acidity. COX-2 is involved in pathways that lead to inflammation (swelling), pain, and fever. The symptoms that COX-2 leads to are unpleasant and unwanted. Inhibitors have been looked at to inhibit the function of COX-2 in order to reduce the symptoms. However, when COX has been inhibited in the past, there have been more unwanted symptoms because the inhibitor does not release easily. | |||
== Function == | == Function == | ||
