2zb1: Difference between revisions
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|PDB= 2zb1 |SIZE=350|CAPTION= <scene name='initialview01'>2zb1</scene>, resolution 2.500Å | |PDB= 2zb1 |SIZE=350|CAPTION= <scene name='initialview01'>2zb1</scene>, resolution 2.500Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=GK4:'>GK4</scene> | |LIGAND= <scene name='pdbligand=GK4:N-(CYCLOPROPYLMETHYL)-2'-METHYL-5'-(5-METHYL-1,3,4-OXADIAZOL-2-YL)BIPHENYL-4-CARBOXAMIDE'>GK4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2zaz|2ZAZ]], [[2zb0|2ZB0]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zb1 OCA], [http://www.ebi.ac.uk/pdbsum/2zb1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2zb1 RCSB]</span> | |||
}} | }} | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Somers, D O.]] | [[Category: Somers, D O.]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:20:01 2008'' | ||
Revision as of 02:20, 31 March 2008
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| 2zb1, resolution 2.500Å | |||||||||||||
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| Ligands: | GK4, GOL | ||||||||||||
| Activity: | Mitogen-activated protein kinase, with EC number 2.7.11.24 | ||||||||||||
| Related: | 2ZAZ, 2ZB0
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of P38 in complex with biphenyl amide inhibitor
Overview
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
About this Structure
2ZB1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306
Page seeded by OCA on Mon Mar 31 05:20:01 2008
