5ywy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 5ywy~~ is ~~ON HOLD until Paper Publication~~

==Crystal structure of the clinically important GPCR in complex with functional antibody.==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5ywy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWY FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7UR:4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic+acid'>7UR</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ywy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywy OCA], [http://pdbe.org/5ywy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywy RCSB], [http://www.ebi.ac.uk/pdbsum/5ywy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywy ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PE2R4_HUMAN PE2R4_HUMAN]] Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

__TOC__

</StructureSection>

[[Category: Horita, S]]

[[Category: Iwata, S]]

[[Category: Kobayashi, T]]

[[Category: Morimoto, K]]

[[Category: Suno, R]]

[[Category: Toyoda, Y]]

[[Category: Functional antibody]]

[[Category: G-protein coupled receptor]]

[[Category: Lipid mediator]]

[[Category: Membrane protein]]

[[Category: Signaling protein-immune system]]

[[Category: Signaling protein-immune system complex]]

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-'''Unreleased structure'''
-The entry 5ywy is ON HOLD  until Paper Publication
+==Crystal structure of the clinically important GPCR in complex with functional antibody.==
+<StructureSection load='5ywy' size='340' side='right' caption='[[5ywy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ywy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWY FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7UR:4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic+acid'>7UR</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ywy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywy OCA], [http://pdbe.org/5ywy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywy RCSB], [http://www.ebi.ac.uk/pdbsum/5ywy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywy ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PE2R4_HUMAN PE2R4_HUMAN]] Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
+__TOC__
+</StructureSection>
+[[Category: Horita, S]]
+[[Category: Iwata, S]]
+[[Category: Kobayashi, T]]
+[[Category: Morimoto, K]]
+[[Category: Suno, R]]
+[[Category: Toyoda, Y]]
+[[Category: Functional antibody]]
+[[Category: G-protein coupled receptor]]
+[[Category: Lipid mediator]]
+[[Category: Membrane protein]]
+[[Category: Signaling protein-immune system]]
+[[Category: Signaling protein-immune system complex]]