6irx: Difference between revisions

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'''Unreleased structure'''


The entry 6irx is ON HOLD
==Crystal structure of the zebrafish cap-specific adenosine methyltransferase==
<StructureSection load='6irx' size='340' side='right' caption='[[6irx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6irx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IRX FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6irx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irx OCA], [http://pdbe.org/6irx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irx RCSB], [http://www.ebi.ac.uk/pdbsum/6irx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irx ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
N (6)-methyladenosine (m(6)A), a major modification of mRNAs, plays critical roles in RNA metabolism and function. In addition to the internal m(6)A, N (6), 2'-O-dimethyladenosine (m(6)Am) is present at the transcription start nucleotide of capped mRNAs in vertebrates. However, its biogenesis and functional role remain elusive. Using a reverse genetics approach, we identified PCIF1, a factor that interacts with the Ser5-phosphorylated C-terminal domain of RNA polymerase II, as cap-specific adenosine methyltransferase (CAPAM) responsible for N (6)-methylation of m(6)Am. Crystal structure of CAPAM in complex with substrates revealed the molecular basis of cap-specific m(6)A formation. A transcriptome-wide analysis revealed that N (6)-methylation of m(6)Am promotes the translation of capped mRNAs. Thus, a cap-specific m(6)A writer promotes translation of mRNAs starting from m(6)Am.


Authors: Hirano, S., Nishimasu, H., Ishitani, R., Nureki, O.
Cap-specific terminal N (6)-methylation of RNA by an RNA polymerase II-associated methyltransferase.,Akichika S, Hirano S, Shichino Y, Suzuki T, Nishimasu H, Ishitani R, Sugita A, Hirose Y, Iwasaki S, Nureki O, Suzuki T Science. 2018 Nov 22. pii: science.aav0080. doi: 10.1126/science.aav0080. PMID:30467178<ref>PMID:30467178</ref>


Description: Crystal structure of the zebrafish cap-specific adenosine methyltransferase
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Nureki, O]]
<div class="pdbe-citations 6irx" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Hirano, S]]
[[Category: Hirano, S]]
[[Category: Ishitani, R]]
[[Category: Nishimasu, H]]
[[Category: Nishimasu, H]]
[[Category: Ishitani, R]]
[[Category: Nureki, O]]
[[Category: M6a]]
[[Category: Methyltransferase]]
[[Category: N6-methyladenosine]]
[[Category: Rna methylation]]
[[Category: Transferase]]
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