3fdn: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity== | ==Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity== | ||
<StructureSection load='3fdn' size='340' side='right' caption='[[3fdn]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3fdn' size='340' side='right' caption='[[3fdn]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| Line 5: | Line 6: | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMH:N-[3-(ACETYLAMINO)PHENYL]-5-{(2E)-2-[(4-METHOXYPHENYL)METHYLIDENE]HYDRAZINO}-3-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE'>MMH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMH:N-[3-(ACETYLAMINO)PHENYL]-5-{(2E)-2-[(4-METHOXYPHENYL)METHYLIDENE]HYDRAZINO}-3-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE'>MMH</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fdn OCA], [http://pdbe.org/3fdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fdn RCSB], [http://www.ebi.ac.uk/pdbsum/3fdn PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fdn OCA], [http://pdbe.org/3fdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fdn RCSB], [http://www.ebi.ac.uk/pdbsum/3fdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fdn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 13: | Line 14: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/3fdn_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fd/3fdn_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 50: | Line 51: | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Polymorphism]] | |||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Virtual screening]] | [[Category: Virtual screening]] | ||
[[Category: X-ray co-crystal analysis]] | [[Category: X-ray co-crystal analysis]] | ||
