Exophilin: Difference between revisions
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<StructureSection load=' | <StructureSection load='4np9' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
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* EXP-1 or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | * EXP-1 or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | ||
* EXP-2 or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br /> | * EXP-2 or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br /> | ||
* EXP-3 or '''melanophilin''' links [[Myosin]] Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity<ref>PMID:15760894</ref>.<br /> | * EXP-3 or '''melanophilin''' links [[Myosin]] Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity<ref>PMID:15760894</ref>.<br /> | ||
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis<ref>PMID:25919460</ref>. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease<ref>PMID:24200817</ref>. | EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis<ref>PMID:25919460</ref>. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease<ref>PMID:24200817</ref>. EXP-4 or '''synaptotagmin-like protein 2''' is associated with the metastatic potential of ovarian carcinoma<ref>PMID:27220283</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
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**[[3fdw]] – hEXP C2 domain <br /> | **[[3fdw]] – hEXP C2 domain <br /> | ||
*Exophilin-3 or | *Exophilin-3 or synaptotagmin-like protein 2A or melanophilin | ||
**[[2zet]] – mEXP SLP homology domain + RAB-27A - mouse<br /> | **[[2zet]] – mEXP SLP homology domain + RAB-27A - mouse<br /> | ||
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**[[4lx2]] – mEXP SLP globular tail domain + myosin-VA <br /> | **[[4lx2]] – mEXP SLP globular tail domain + myosin-VA <br /> | ||
*Exophilin-4 or | *Exophilin-4 or synaptotagmin-like protein 2 | ||
**[[3bc1]] – hEXP | **[[3bc1]] – hEXP Rab-binding domain + Rab27A<br /> | ||
}} | }} | ||
== References == | == References == | ||
