Sandbox Reserved 1475: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
The structure was based on the mitochondrial aldehyde dehydrogenase type two. RalDH2 in a monomer made up of 3 domains: a nucleotide-binding domain (1-136, 161-270), a catalytic domain (271-484), and a tetramerization domain (137-160, 485-484) as shown in Figure 1.<ref name="Lamb AL, Newcomber ME" /> [[Image:3 Domains of RalDH2.png|thumb|upright=2| '''Figure 1''' Nucleotide-binding domain - orange, Catalytic domain - green, Tetramerization domain - blue. Imagine modified in Chimera from (PDB entry [[1bi9]]). Chain D shown with NAD substrate shown in pink]] | The structure was based on the mitochondrial aldehyde dehydrogenase type two. RalDH2 in a monomer made up of 3 domains: a nucleotide-binding domain (1-136, 161-270), a catalytic domain (271-484), and a tetramerization domain (137-160, 485-484) as shown in Figure 1.<ref name="Lamb AL, Newcomber ME" /> [[Image:3 Domains of RalDH2.png|thumb|upright=2| '''Figure 1''' Nucleotide-binding domain - orange, Catalytic domain - green, Tetramerization domain - blue. Imagine modified in Chimera from (PDB entry [[1bi9]]). Chain D shown with NAD substrate shown in pink]] | ||
The tetramer can be envisioned as an "X", with nucleotide-binding sites at the tips of the "X", and the tetramerization domains as the equatorial portion of the "X" (Figure 2). <Structure load='1bi9' size='350' frame='true' align='right' caption='' scene='' /> | The tetramer can be envisioned as an "X", with nucleotide-binding sites at the tips of the "X", and the tetramerization domains as the equatorial portion of the "X" (Figure 2). | ||
<Structure load='1bi9' size='350' frame='true' align='right' caption='Nucleotide-binding domain - orange, Catalytic domain - green, Tetramerization domain - blue (PDB entry [[1bi9]])' scene='Insert optional scene name here' /> | |||
