Sulfatase-modifying factor: Difference between revisions
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<StructureSection load='2aij' size=' | <StructureSection load='2aij' size='400' side='right' caption='Glycosylated human sulfatase-modifying factor 1 (cyan) complex with arylsulfatase peptide (magenta), Ca+2 ion (green) and Cl- ion (green) (PDB code [[2aij]]) ' scene='80/801257/Cv/1'> | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
The structure of SUMF1 complex with its substrate sulfatase terminal peptide CTPSR. | The structure of SUMF1 complex with its substrate sulfatase terminal peptide CTPSR. SUMF1 active site contains 2 cysteine residues and mutating either of them to serine results in an inactive enzyme. Cys341 was found to be responsible for substrate binding and makes a Cys-Cys bond to the peptide cysteine residue. The peptide binds at the surface of SUMF1 in an extended conformation making numerous interactions with the protein<ref>PMID:16368756</ref>. | ||
</StructureSection> | </StructureSection> | ||
