Sandbox Reserved 1475: Difference between revisions
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== Disease == | == Disease == | ||
[[Image:Embryo of RalDH2.png|thumb|left | [[Image:Embryo of RalDH2.png|thumb|left| [[Figure 7]] "Morphological abnormalities of RalDH2 knock out embryos".<ref name="Embryonic retinoic acid synthesis" />]] | ||
Multiple complications can occur if there is a deficiency of RalDH2 in mammals. If there were to be a RalDH2 deficiency during the embryonic development, possible congenital malformations can occur. The complications include defects such as lack of axial rotation, incomplete neural tube closure, and lack of heart looping and chamber morphogenesis. <ref name="Embryonic retinoic acid synthesis">PMID:10192400</ref> With the study of mouse with their RalDH2 emzyne knocked out, hearts consisted of single, medial, dilated cavities.<ref name="Embryonic retinoic acid synthesis" /> The mice displayed their frontonasal region to be truncated, and their otocysts to be reduced.<ref name="Embryonic retinoic acid synthesis" /> In [[Figure 7]], the comparison of wild-type embryos compared to ones that are RalDH2 negative. It is visible to see that there is lack of embryonic turning, associated with a truncation of the posterior region.<ref name="Embryonic retinoic acid synthesis" /> The WT 8.5 doc embryo is the wild-type embryo before turning has occurred. Section b displays a wild-type embryo compared to defective embryos, section c-d. The e and f show the embryos of a wild-type embryo compared to one that was low in the RalDH2 enzyme, respectfully. | Multiple complications can occur if there is a deficiency of RalDH2 in mammals. If there were to be a RalDH2 deficiency during the embryonic development, possible congenital malformations can occur. The complications include defects such as lack of axial rotation, incomplete neural tube closure, and lack of heart looping and chamber morphogenesis. <ref name="Embryonic retinoic acid synthesis">PMID:10192400</ref> With the study of mouse with their RalDH2 emzyne knocked out, hearts consisted of single, medial, dilated cavities.<ref name="Embryonic retinoic acid synthesis" /> The mice displayed their frontonasal region to be truncated, and their otocysts to be reduced.<ref name="Embryonic retinoic acid synthesis" /> In [[Figure 7]], the comparison of wild-type embryos compared to ones that are RalDH2 negative. It is visible to see that there is lack of embryonic turning, associated with a truncation of the posterior region.<ref name="Embryonic retinoic acid synthesis" /> The WT 8.5 doc embryo is the wild-type embryo before turning has occurred. Section b displays a wild-type embryo compared to defective embryos, section c-d. The e and f show the embryos of a wild-type embryo compared to one that was low in the RalDH2 enzyme, respectfully. | ||
