5y08: Difference between revisions
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==Solution structure of the apo doublet acyl carrier protein from prodigiosin biosynthesis== | |||
<StructureSection load='5y08' size='340' side='right' caption='[[5y08]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5y08]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y08 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y08 OCA], [http://pdbe.org/5y08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y08 RCSB], [http://www.ebi.ac.uk/pdbsum/5y08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y08 ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PIGH_SERS3 PIGH_SERS3]] Involved in the biosynthesis of 4-methoxy-2,2'-bipyrrole-5-carbaldehyde (MBC), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Carrier of the L-malonyl group (malonyl-S-PigH), which is decarboxylated by PigJ to yield a C2 carbanion acetyl-S-PigH. Then the pyrrolyl group of pyrrolyl-S-cysteinyl PigJ intermediate is captured by the C2 carbanion acetyl-S-PigH to yield the pyrrolyl-beta-ketoacyl-S-PigH. In the last step, PigH catalyzes the decarboxylative condensation between the pyrrolyl-beta-ketoacyl (pyrrolyl-beta-ketoacyl-S-PigH) and L-serine to yield 4-hydroxy-2,2'-bipyrrole-5-methanol (HBM).<ref>PMID:15853884</ref> <ref>PMID:17002325</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Wattana-amorn, P]] | |||
[[Category: Acyl carrier protein]] | |||
[[Category: Biosynthetic protein]] | |||
