5yk5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5yk5 is ~~ON HOLD until Dec 13 2019~~

==structure of the human Lamtor4-Lamtor5 complex==

~~Authors~~: Wu, G., Mu, Z.

== Structural highlights ==

<table><tr><td colspan='2'>[[5yk5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YK5 FirstGlance]. <br>

~~Description~~: ~~structure~~ of the ~~human Lamtor4~~-~~Lamtor5 complex~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk5 OCA], [http://pdbe.org/5yk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5yk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk5 ProSAT]</span></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Mu, Z]]

[[Category: Wu, G]]

[[Category: Cellular signal transduction pathway]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yk5 is ON HOLD  until Dec 13 2019
+==structure of the human Lamtor4-Lamtor5 complex==
+<StructureSection load='5yk5' size='340' side='right' caption='[[5yk5]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-Authors: Wu, G., Mu, Z.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yk5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YK5 FirstGlance]. <br>
-Description: structure of the human Lamtor4-Lamtor5 complex
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk5 OCA], [http://pdbe.org/5yk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5yk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk5 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref>  [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Mu, Z]]
 [[Category: Wu, G]]
+[[Category: Cellular signal transduction pathway]]
+[[Category: Signaling protein]]