6dhb: Difference between revisions
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==Crystal structure of the human TIM-3 with bound Calcium== | |||
<StructureSection load='6dhb' size='340' side='right' caption='[[6dhb]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dhb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DHB FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dhb OCA], [http://pdbe.org/6dhb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dhb RCSB], [http://www.ebi.ac.uk/pdbsum/6dhb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dhb ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[ | == Function == | ||
[[ | [[http://www.uniprot.org/uniprot/HAVR2_HUMAN HAVR2_HUMAN]] Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.<ref>PMID:14556005</ref> <ref>PMID:16286920</ref> | ||
[[ | == References == | ||
[[ | <references/> | ||
[[ | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Blumberg, R S]] | |||
[[Category: Bonsor, D]] | [[Category: Bonsor, D]] | ||
[[Category: Gandhi, A K]] | |||
[[Category: Huang, Y H]] | |||
[[Category: Kim, W M]] | |||
[[Category: Kuchroo, V]] | [[Category: Kuchroo, V]] | ||
[[Category: Petsko, G A]] | |||
[[Category: Sun, Z Y]] | |||
[[Category: Sundberg, E]] | |||
[[Category: Immune system]] | |||
[[Category: T cell immunoglobulin mucin-3 immunological tolerance]] | |||