6e59: Difference between revisions
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The | ==Crystal structure of the human NK1 tachykinin receptor== | ||
<StructureSection load='6e59' size='340' side='right' caption='[[6e59]], [[Resolution|resolution]] 3.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6e59]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E59 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L76:1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine'>L76</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e59 OCA], [http://pdbe.org/6e59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e59 RCSB], [http://www.ebi.ac.uk/pdbsum/6e59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e59 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NK1R_HUMAN NK1R_HUMAN]] This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Borek, D]] | |||
[[Category: Chapman, K]] | |||
[[Category: Clark, L]] | |||
[[Category: Rosenbaum, D M]] | |||
[[Category: Shao, Z]] | |||
[[Category: Wang, J]] | |||
[[Category: Xu, Q]] | |||
[[Category: Yin, J]] | |||
[[Category: G protein-coupled receptor fusion protein]] | |||
[[Category: Signaling protein]] | |||
Revision as of 06:45, 12 December 2018
Crystal structure of the human NK1 tachykinin receptor
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