6n34: Difference between revisions
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==Crystal structure of the BTB domain of Human NS1-BP== | |||
<StructureSection load='6n34' size='340' side='right' caption='[[6n34]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6n34]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N34 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n34 OCA], [http://pdbe.org/6n34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n34 RCSB], [http://www.ebi.ac.uk/pdbsum/6n34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n34 ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NS1BP_HUMAN NS1BP_HUMAN]] Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.<ref>PMID:16582008</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chook, Y M]] | |||
[[Category: Fontoura, B]] | |||
[[Category: Padavannil, A]] | |||
[[Category: Shang, G]] | |||
[[Category: Zhang, K]] | |||
[[Category: Mrna export]] | |||
[[Category: Splicing]] | |||
Revision as of 06:58, 12 December 2018
Crystal structure of the BTB domain of Human NS1-BP
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