Sandbox Reserved 1474: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 105: | Line 105: | ||
====Cross reactions in vitro ligand binding studies==== | ====Cross reactions in vitro ligand binding studies==== | ||
It did not bind endogenous neurotransmitters or other medications and was not bound by protein C1q, thus it is unlikely to stimulate in vivo complement-dependent cytotoxicity. <ref name="Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use" /> | It did not bind endogenous neurotransmitters or other medications and was not bound by protein C1q, thus it is unlikely to stimulate in vivo complement-dependent cytotoxicity. <ref name="Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use" /> | ||
Table 2 <ref name="Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use" />Ligands tested in Ch-mAb7F9 cross-reactivity study | |||
Related stimulants Neurotransmitters Medications Drugs of abuse | |||
(+)-Methamphetamine Dopamine (+)-Pseudoephedrine Cocaine | |||
(+)-Amphetamine (-)-Norepinephrine (+)-Norpseudoephedrine Morphine | |||
(+)-MDMA (-)-Epinephrine (-)-Phenylephrine Phencyclidine | |||
(-)-MDMA Serotonin (± )-Ephedrine | |||
(+)-MDA γ-aminobutyric acid 2-Phenylethylamine | |||
L-Glutamate Tyramine | |||
====Isothermal titration calorimetry potency studies==== | ====Isothermal titration calorimetry potency studies==== | ||
Isothermal titration calorimetry analysis of ch-mAb7F9 binding to METH provided thermodynamic and stoichiometry measurements.<ref name="Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use" /> | Isothermal titration calorimetry analysis of ch-mAb7F9 binding to METH provided thermodynamic and stoichiometry measurements.<ref name="Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use" /> | ||
