Sandbox Reserved 1482: Difference between revisions
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== '''Coagulation Factor VIII (3cdz)''' == | == '''Coagulation Factor VIII (3cdz)''' == | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
Factor VIII, also known as anti-haemophilic factor (AHF), is an essential blood-clotting protein consisting of 2332 residues isolated from Homo sapiens, whose gene is located on the X chromosome. | '''Factor VIII''', also known as anti-haemophilic factor (AHF), is an essential blood-clotting protein consisting of 2332 residues isolated from Homo sapiens, whose gene is located on the X chromosome. | ||
Factor VIII is produced in the liver (in liver sinusoidal cells) and outside (in endothelial cells) and acts in the intrinsic pathway of blood coagulation. It is actually a plasma glycoprotein whose deficiency or absence causes a bleeding disorder: haemophilia A. | Factor VIII is produced in the liver (in liver sinusoidal cells) and outside (in endothelial cells) and acts in the intrinsic pathway of blood coagulation. It is actually a plasma glycoprotein whose deficiency or absence causes a bleeding disorder: haemophilia A. | ||
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== History == | == History == | ||
1937: first use of the factor VIII (known at this period as “Antihemophilic Globulin”) to cure the blood coagulation disorder of haemophilia patients thanks to the discovery of F.H.L Patek and A.J Taylor. [10] | '''1937''': first use of the factor VIII (known at this period as “Antihemophilic Globulin”) to cure the blood coagulation disorder of haemophilia patients thanks to the discovery of F.H.L Patek and A.J Taylor. [10] | ||
1964: Usual utilisation of concentrated factor VIII to treat haemophilia. | '''1964''': Usual utilisation of concentrated factor VIII to treat haemophilia. | ||
1984: Factor VIII was first characterized by scientists at Genentech | '''1984''': Factor VIII was first characterized by scientists at Genentech | ||
== Function == | == Function == | ||
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Haemophilia A can be mild, moderate, or severe, depending on the level of Factor VIII clotting activity: | Haemophilia A can be mild, moderate, or severe, depending on the level of Factor VIII clotting activity: | ||
• Severe haemophilia A: factor VIII’s proportion in the blood ≤ 1% | • Severe haemophilia A: factor VIII’s proportion in the blood ≤ 1% | ||
• Moderate haemophilia A: 1% ≤ factor VIII’s proportion in the blood ≤ 5% | • Moderate haemophilia A: 1% ≤ factor VIII’s proportion in the blood ≤ 5% | ||
• Mild haemophilia A: 6% ≤ factor VIII’s proportion in the blood ≤ 40% [6] | • Mild haemophilia A: 6% ≤ factor VIII’s proportion in the blood ≤ 40% [6] | ||
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The main medication to treat haemophilia A is concentrated factor VIII product, called clotting factor or simply factor. Getting this simply factor is therefore a major concern for haemophilia-affected people. | The main medication to treat haemophilia A is concentrated factor VIII product, called clotting factor or simply factor. Getting this simply factor is therefore a major concern for haemophilia-affected people. | ||
Nowadays, recombinant coagulation factor VIII products, which are developed in a lab through the use of DNA technology, may preclude the use of human-derived pools of donor-sourced plasm. [7] | Nowadays, recombinant coagulation factor VIII products, which are developed in a lab through the use of DNA technology, may preclude the use of human-derived pools of donor-sourced plasm. [7] | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
wiki | |||
<references/> | <references/> | ||
