Sandbox Reserved 1482: Difference between revisions
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Then, no longer protected by von Willebrand factor, factor VIIIa is proteolytically inactivated and quickly cleared from the blood stream, whereas, factor Xa becomes able (with the help of other factors) to stop the bleeding by forming a blood clot. | Then, no longer protected by von Willebrand factor, factor VIIIa is proteolytically inactivated and quickly cleared from the blood stream, whereas, factor Xa becomes able (with the help of other factors) to stop the bleeding by forming a blood clot. | ||
== Structure == | == Structure == | ||
'''Primary Structure''' | '''Primary Structure''' | ||
In humans, factor VIII is encoded by the F8 gene. [2] This gene maps on the most distal band of the long arm of the X-chromosome (region Xq28). It is 186kb in size (0.1% of the whole size of the chromosome) and contains 26 exons. [4] | In humans, factor VIII is encoded by the F8 gene. [2] This gene maps on the most distal band of the long arm of the X-chromosome (region Xq28). It is 186kb in size (0.1% of the whole size of the chromosome) and contains 26 exons. [4] | ||
'''Secondary Structure''' | '''Secondary Structure''' | ||
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Both chains are no covalently associated through to a calcium ion to form the active heterodimers. [3] This complex is the pro-coagulant factor VIIIa. | Both chains are no covalently associated through to a calcium ion to form the active heterodimers. [3] This complex is the pro-coagulant factor VIIIa. | ||
Such an association is indispensable for the functioning of the factor VIII. | Such an association is indispensable for the functioning of the factor VIII. | ||
'''Ligands''' | '''Ligands''' | ||
