3c6g: Difference between revisions
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|PDB= 3c6g |SIZE=350|CAPTION= <scene name='initialview01'>3c6g</scene>, resolution 2.800Å | |PDB= 3c6g |SIZE=350|CAPTION= <scene name='initialview01'>3c6g</scene>, resolution 2.800Å | ||
|SITE= <scene name='pdbsite=AC1:Bcd+Binding+Site+For+Residue+B+800'>AC1</scene>, <scene name='pdbsite=AC2:Bcd+Binding+Site+For+Residue+B+801'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Residue+A+601'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Residue+B+601'>AC4</scene>, <scene name='pdbsite=AC5:Vd3+Binding+Site+For+Residue+B+700'>AC5</scene>, <scene name='pdbsite=AC6:Vd3+Binding+Site+For+Residue+A+701'>AC6</scene>, <scene name='pdbsite=AC7:Unx+Binding+Site+For+Residue+B+4'>AC7</scene>, <scene name='pdbsite=AC8:Unx+Binding+Site+For+Residue+B+5'>AC8</scene> and <scene name='pdbsite=AC9:Unx+Binding+Site+For+Residue+B+6'>AC9</scene> | |SITE= <scene name='pdbsite=AC1:Bcd+Binding+Site+For+Residue+B+800'>AC1</scene>, <scene name='pdbsite=AC2:Bcd+Binding+Site+For+Residue+B+801'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Residue+A+601'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Residue+B+601'>AC4</scene>, <scene name='pdbsite=AC5:Vd3+Binding+Site+For+Residue+B+700'>AC5</scene>, <scene name='pdbsite=AC6:Vd3+Binding+Site+For+Residue+A+701'>AC6</scene>, <scene name='pdbsite=AC7:Unx+Binding+Site+For+Residue+B+4'>AC7</scene>, <scene name='pdbsite=AC8:Unx+Binding+Site+For+Residue+B+5'>AC8</scene> and <scene name='pdbsite=AC9:Unx+Binding+Site+For+Residue+B+6'>AC9</scene> | ||
|LIGAND= <scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VD3:(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL'>VD3 | |LIGAND= <scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VD3:(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL'>VD3</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= CYP2R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= CYP2R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6g OCA], [http://www.ebi.ac.uk/pdbsum/3c6g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3c6g RCSB]</span> | |||
}} | }} | ||
'''Crystal structure of CYP2R1 in complex with vitamin D3''' | '''Crystal structure of CYP2R1 in complex with vitamin D3''' | ||
==Disease== | |||
Known disease associated with this structure: Rickets due to defect in vitamin D 25-hydroxylation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608713 608713]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: Tempel, W.]] | [[Category: Tempel, W.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: cytochrome p450]] | [[Category: cytochrome p450]] | ||
[[Category: disease mutation]] | [[Category: disease mutation]] | ||
| Line 49: | Line 51: | ||
[[Category: vitamin d3]] | [[Category: vitamin d3]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:30:55 2008'' | ||
