High affinity nerve growth factor receptor: Difference between revisions
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== Function == | == Function == | ||
'''High affinity nerve growth factor receptor''' (TrkA) is a tyrosine kinase receptor. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation<ref name="TrkA">PMID:9759973</ref>. | '''High affinity nerve growth factor receptor''' (TrkA) is a tyrosine kinase receptor. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation<ref name="TrkA">PMID:9759973</ref>. | ||
== Relevance == | == Relevance == | ||
TrkA has a role in the pathogenesis of psoriasis and its inhibitors are studied in the development of novel therapeutics for the disease<ref name="TrkA"/>. | TrkA has a role in the pathogenesis of psoriasis and its inhibitors are studied in the development of novel therapeutics for the disease<ref name="TrkA"/>. TrkA inhibition may be a novel therapeutic approach to Alzheimer disease<ref>PMID:24531152</ref> and a new method to treat intractable pain<ref>PMID:26452158</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
