DNA ligase: Difference between revisions
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== Function == | == Function == | ||
'''DNA ligase''' (LigD) is an enzyme which repairs single-stranded breaks in a double-stranded DNA. LigD is activated, in a species-dependent manner, by hydrolysis of ATP or NAD+.<br /> | '''DNA ligase''' (LigD) is an enzyme which repairs single-stranded breaks in a double-stranded DNA. LigD is activated, in a species-dependent manner, by hydrolysis of ATP or NAD+. See also [[ATP-dependent DNA ligase from bacteriophage T7]].<br /> | ||
* Mammalian '''LigD I''' ligates the nascent DNA of the lagging strand.<br /> | * Mammalian '''LigD I''' ligates the nascent DNA of the lagging strand.<br /> | ||
* '''LigD III''' complexes with XRCC1 in the process of nucleotide excision repair.<br /> | * '''LigD III''' complexes with XRCC1 in the process of nucleotide excision repair.<br /> | ||
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**[[2fao]] - PaLigD polymerase domain – ''Pseudomonas aeruginosa''<br /> | **[[2fao]] - PaLigD polymerase domain – ''Pseudomonas aeruginosa''<br /> | ||
**[[2faq]], [[2far]] - PaLigD polymerase domain + ATP + Mn<br /> | **[[2faq]], [[2far]] - PaLigD polymerase domain + ATP + Mn<br /> | ||
**[[1a0i]] – LigD + ATP – Bacteriophage T7<br /> | **[[1a0i]] – LigD (mutant) + ATP – Bacteriophage T7<br /> | ||
**[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br /> | **[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br /> | ||
**[[4d05]] – LigD + AMP - ''Psychromonas'' <br /> | **[[4d05]] – LigD + AMP - ''Psychromonas'' <br /> | ||
