3m4w

Structural basis for the negative regulation of bacterial stress response by RseB

spinqualitylabelsall models 3m4w, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3m4w is a 8 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Related: 2p4b Gene: RseB (Amino Acids 24-318) (ECOLI), RseA (Amino Acids 121-216) (ECOLI) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [RSEB_ECOLI] Seems to modulate the activity of RpoE (sigma-E). [RSEA_ECOLI] Negative regulator of RpoE. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The sigmaE-dependent stress response in bacterial cells is initiated by the DegS- and RseP-regulated intramembrane proteolysis of a membrane-spanning antisigma factor, RseA. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. In the crystal structure of the periplasmic domain of RseA bound to RseB, the DegS cleavage site of RseA is unstructured, however, its P1 residue is buried in the hydrophobic pocket of RseB, which suggests that RseB binding blocks the access of DegS to the cleavage site. Structural basis for the negative regulation of bacterial stress response by RseB.,Kim DY, Kwon E, Choi J, Hwang HY, Kim KK Protein Sci. 2010 Jun;19(6):1258-63. PMID:20512978 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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