Sandbox Reserved 1491: Difference between revisions
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Two families of histone-lysine demethylases (KDM) have been identified as follows : the flavin (FAD) -dependent lysine-specific demethylases and the Fe(II)-dependent Jumonji C (JmjC) family. JmjC[1] is subfamily of histone demethylases which regroups several proteins containing a specific catalytic domain called Jmjc found in 2xml structure. KDM4 demethylases belong to the JmjC family and contains six members : KDM4A-F. | Two families of histone-lysine demethylases (KDM) have been identified as follows : the flavin (FAD) -dependent lysine-specific demethylases and the Fe(II)-dependent Jumonji C (JmjC) family. JmjC[1] is subfamily of histone demethylases which regroups several proteins containing a specific catalytic domain called Jmjc found in 2xml structure. KDM4 demethylases belong to the JmjC family and contains six members : KDM4A-F. | ||
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KDM4C/JMJD2 is a protein which converts specific trimethylated histone residues to the dimethylated form. Indeed, it catalyzes the demethylation of both histone H3 Lysine 9 (H3K9me3) and Lysine 36 (H3K36me3) by hydroxylation of the lysine methyl group leading to a dissociation of the methyl group from the lysine histone tail. KDM4C employs 2-oxoglutarate (OG), Fe2+ and oxygen as cosubstrates to promote its enzymatic reaction, thus the dissociation of methyl groups. | KDM4C/JMJD2 is a protein which converts specific trimethylated histone residues to the dimethylated form. Indeed, it catalyzes the demethylation of both histone H3 Lysine 9 (H3K9me3) and Lysine 36 (H3K36me3) by hydroxylation of the lysine methyl group leading to a dissociation of the methyl group from the lysine histone tail. KDM4C employs 2-oxoglutarate (OG), Fe2+ and oxygen as cosubstrates to promote its enzymatic reaction, thus the dissociation of methyl groups. | ||
