Sandbox Reserved 1485: Difference between revisions
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==KAP-1== | ==KAP-1== | ||
KAP-1 (KRAB – associated protein 1) is a protein of the KRAB protein family (Krüppel-associated box). These KRAB domain is a domain of repression which is encoded by many zinc finger protein-based transcription factors (KRAB zinc finger proteins or KRAP-ZFPs proteins). | KAP-1 (KRAB – associated protein 1) is a protein of the KRAB protein family (Krüppel-associated box). These KRAB domain is a domain of repression which is encoded by many zinc finger protein-based transcription factors (KRAB zinc finger proteins or KRAP-ZFPs proteins). | ||
KAP-1 is also known as Tripartite motif-containing 28 (TRIM28) and as transcriptional intermediary factor 1β (TIF1β). Indeed, KAP-1 is one of the TRIM proteins (wich code for TRIM genes). Among these TRIM proteins, there is the TIF1 family proteins, of which is part KAP-1 (that’s why KAP-1 is also known as TIF1β and TRIM28). | KAP-1 is also known as Tripartite motif-containing 28 (TRIM28) and as transcriptional intermediary factor 1β (TIF1β). Indeed, KAP-1 is one of the TRIM proteins (wich code for TRIM genes). Among these TRIM proteins, there is the TIF1 family proteins, of which is part KAP-1 (that’s why KAP-1 is also known as TIF1β and TRIM28). | ||
KAP-1 is localized in the nucleus and interacts whith specific regions of the chromatin. This protein plays role in many phenomena as the regulation of transcription, the cellular differenciation and proliferation or even the reparation of DNA damages. Sumoylation can activate the protein in many of its mechanisms while phosphorylation can deactivate the protein. | KAP-1 is localized in the nucleus and interacts whith specific regions of the chromatin. This protein plays role in many phenomena as the regulation of transcription, the cellular differenciation and proliferation or even the reparation of DNA damages. Sumoylation can activate the protein in many of its mechanisms while phosphorylation can deactivate the protein. | ||
