Sandbox Reserved 1491: Difference between revisions
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==Preview== | ==Preview== | ||
2xml is a 2 chain structure. This domain belongs to the Human KDM4C protein. | 2xml is a 2 chain structure. This domain belongs to the [https://en.wikipedia.org/wiki/Human Human] KDM4C protein. | ||
[https://en.wikipedia.org/wiki/KDM4C KDM4C] is a histone demethylase involved in the specific demethylation of trimethylated residues (Lys 9 and Lys 36 of histone 3). | [https://en.wikipedia.org/wiki/KDM4C KDM4C] is a histone demethylase involved in the specific demethylation of trimethylated residues (Lys 9 and Lys 36 of histone 3). | ||
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== Function == | == Function == | ||
Genes regulation is directly related to the condensation state of the [https://en.wikipedia.org/wiki/Chromatin chromatin]. Indeed, chromatin can be in the form of heterochromatin (condensed form of DNA) or euchromatin (relaxed form of DNA) which correspond respectively to the transcriptionally silent and active forms of DNA. Chromatin is composed of DNA wrapped around[https://en.wikipedia.org/wiki/Histone histone] octamers forming nucleosomes. The histone tails residues can be acetylated, methylated or demethylated by enzymes in order to modify chromatin state and therefore gene expression. Different types of proteins involved in this process exist, such as histone acetylase (HAT), histone methylase (HMT) or histone demethylase (HDM). | Genes regulation is directly related to the condensation state of the [https://en.wikipedia.org/wiki/Chromatin chromatin]. Indeed, chromatin can be in the form of [https://en.wikipedia.org/wiki/Heterochromatin heterochromatin] (condensed form of DNA) or [https://en.wikipedia.org/wiki/Euchromatin euchromatin] (relaxed form of DNA) which correspond respectively to the transcriptionally silent and active forms of DNA. Chromatin is composed of DNA wrapped around [https://en.wikipedia.org/wiki/Histone histone] octamers forming nucleosomes. The histone tails residues can be [https://en.wikipedia.org/wiki/Acetylation acetylated], [https://en.wikipedia.org/wiki/Methylation methylated] or [https://en.wikipedia.org/wiki/Demethylation demethylated] by enzymes in order to modify chromatin state and therefore gene expression. Different types of proteins involved in this process exist, such as histone acetylase (HAT), histone methylase (HMT) or histone demethylase (HDM). | ||
Two families of [https://en.wikipedia.org/wiki/Demethylase histone-lysine demethylase] (KDM) have been identified as follows : the flavin (FAD) -dependent lysine-specific demethylases and the Fe(II)-dependent Jumonji C (JmjC) family. JmjC[1] is subfamily of histone demethylases which regroups several proteins containing a specific catalytic domain called Jmjc found in 2xml structure. KDM4 demethylases belong to the JmjC family and contains six members : KDM4A-F | Two families of [https://en.wikipedia.org/wiki/Demethylase histone-lysine demethylase] (KDM) have been identified as follows : the flavin (FAD) -dependent lysine-specific demethylases and the Fe(II)-dependent Jumonji C (JmjC) family. JmjC[1] is subfamily of histone demethylases which regroups several proteins containing a specific catalytic domain called Jmjc found in 2xml structure. KDM4 demethylases belong to the JmjC family and contains six members : KDM4A-F | ||
