Sandbox Reserved 1502: Difference between revisions
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== Structure == | == Structure == | ||
HIV-1 integrase is composed of three domains: the N-terminal (residues 1-49), the core domain (residues 50-212) and the C-terminal domain (residues 213-288). The core domain is responsible for the catalytic activity of the enzyme. It contains a three acidic residues, the D,D-35-E motif which plays a key role in catalysis.The N-terminal domain includes the conserved HHCC motif, which binds zinc. The C-terminal domain is less well conserved. [http://www.jbc.org/content/276/26/23213/F2.expansion.html] | |||
[[Image:HIV Integrase sequence.jpg]] | [[Image:HIV Integrase sequence.jpg]] | ||
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== References == | == References == | ||
https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids | https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids | ||
https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids | |||
<references/> | <references/> | ||
